Counteracting dysfunction of regulatory T cells in organ transplantation
نویسندگان
چکیده
منابع مشابه
Counteracting dysfunction of regulatory T cells in organ transplantation.
Regulatory T cells (Tregs) are central in controlling adaptive immunity. The importance of Tregs in preventing autoimmunity has been demonstrated both in experimental models and in patients with mutations in the essential transcription factor Foxp3 (1). This has now been translated to strategies that can exploit this capacity in clinical settings, including either strategies to control Treg num...
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One of the essential protection mechanisms of immune system is Treg cells which play an important role in maintenance ofimmune homeostasis. However, they may also inhibit immune functions against tumor cells. It has been reported that Treg cellsare increased in patients suffering from different types of cancer. Increased number of Treg cells has been shown in tumor lymphnodes, peripheral blood,...
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Dendritic cells (DC) are rare, professional antigen-presenting cells with ability to induce or regulate alloimmune responses. Regulatory DC (DCreg) with potential to down-modulate acute and chronic inflammatory conditions that occur in organ transplantation can be generated in vitro under a variety of conditions. Here, we provide a rationale for evaluation of DCreg therapy in clinical organ tra...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1708493114